Idebenone treatment in Leber's hereditary optic neuropathy.
نویسندگان
چکیده
Valerio Carelli, MD, PhD, Chiara La Morgia, MD, Maria Lucia Valentino, MD, Giovanni Rizzo, MD, PhD, Michele Carbonelli, MD, Anna Maria De Negri, MD, Federico Sadun, MD, Arturo Carta, MD, Silvana Guerriero, MD, Francesca Simonelli, MD, Alfredo A Sadun, MD, PhD, Divya Aggarwal, MD, Rocco Liguori, MD, Patrizia Avoni, MD, PhD, Agostino Baruzzi, MD, Massimo Zeviani, MD, PhD, Pasquale Montagna, MD, Piero Barboni, MD.
منابع مشابه
[Response to idebenone and multivitamin therapy in Leber's hereditary optic neuropathy].
OBJECTIVE To ascertain the efficacy of idebenone and multivitamin treatment in Leber's hereditary optic neuropathy (LHON). METHOD Two patients diagnosed of unilateral LHON were treated with megadoses of idebenone, vitamin C and riboflavin for one year. They were examined clinically before, during and after treatment. RESULTS No improvement of visual function was observed. Despite the ideben...
متن کاملNovel use of idebenone in Leber's hereditary optic neuropathy in Hong Kong.
We report a case of a young Chinese male presenting with sequential, painless, bilateral visual loss in Hong Kong. He was diagnosed to have Leber's hereditary optic neuropathy with genetic workup showing G11778A mutation with over 80% heteroplasmy. He was started on idebenone treatment 11 months after onset of the binocular disease. To our best knowledge, this is the first case of Leber's hered...
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Major advances in understanding the pathogenesis of inherited metabolic disease caused by mitochondrial DNA mutations have yet to translate into treatments of proven efficacy. Leber's hereditary optic neuropathy is the most common mitochondrial DNA disorder causing irreversible blindness in young adult life. Anecdotal reports support the use of idebenone in Leber's hereditary optic neuropathy, ...
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Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a rando-mized, placebo-controlled trial. et al. A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy. Brain (this issue) 2011. Koilkonda RD, Guy J. Leber's hereditary optic neuropathy – gene therapy: from benchtop to bedside. Do idebenone and vitamin therapy shorten the time to...
متن کاملIdebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber’s Hereditary Optic Neuropathy
Leber's hereditary optic neuropathy (LHON) is an inherited disease caused by mutations in complex I of the mitochondrial respiratory chain. The disease is characterized by loss of central vision due to retinal ganglion cell (RGC) dysfunction and optic nerve atrophy. Despite progress towards a better understanding of the disease, no therapeutic treatment is currently approved for this devastatin...
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عنوان ژورنال:
- Brain : a journal of neurology
دوره 134 Pt 9 شماره
صفحات -
تاریخ انتشار 2011